Recently, a team of researchers from the University of Nottingham School of Chemistry discovered a new method that uses visible light to modify bioactive molecules based on the structure of the chemical reaction. This sustainable method is certainly expected to produce or design new drugs compared to conventional methods. The research team is trying to create new ways to develop chemicals using the green, infinite energy of light. The use of visible light in chemical methodologies will help reduce the use of heavy metals and toxic reagents in the long term. The latest study published in natural chemistry focuses on using visible light to activate conjunctiva olefination.
Typically, the development of new drugs or agrochemicals requires a lot of time and investigation before finding the correct structural analogs that enhance the chemical properties or any specific bioactivity. Late-stage functionalization is the process by which chemists typically access analogs by making modifications to complex bioactive molecules. The idea of accessing full analogs through traditional methods is almost impossible because many toxic and expensive chemicals or catalysts as well as longer duration come into play. Thus, researchers have used heavy metals or chemicals toxic to develop new drugs. It is clear that late-stage functionalization could prove to be an effective tool at the time of drug design or development due to its sustainable and practical approach.
The last approach will make it possible to explore new structures and thus increase their potential application for the design or production of new molecules. According to lead researcher Dr. Mattia Silvi, the discovery of the latest fundamental approach will help bring about structural changes in bioactive molecules. The current focus is on using visible light energy, a sustainable method, instead of chemicals or heavy metals to design new derivatives. The research team hopes their latest study will help scientists design and produce new analogues of the bioactive molecules, providing a new tool for future drug development. This research should pave the way for sustainable chemistry.